2-Ethyl-2-imidazoline synthesis
- Product Name:2-Ethyl-2-imidazoline
- CAS Number:930-52-9
- Molecular formula:C5H10N2
- Molecular Weight:98.15
Yield:930-52-9 80%
Reaction Conditions:
in carbon disulfide; for 0.00972222 h;Microwave irradiation;
Steps:
2-methyl-4,5-dihydro-1H-imidazole
General procedure: Microwave assisted reactions were carried out in a domestic microwave oven (Samsung-LCE 2733 GXTL) for realistic control of the microwaves operating at 850 W generating 2450MHz frequency through out the required time.A mixture of nitrile (0.01 mol), ethylenediamine (0.04 mol) and carbon disulphide solvent (0.001mol) was taken in a Erlenmeyer flask. The Erlenmeyer flask was placed in a microwave ovenand irradiated under at low power (100 W) for 30-150 seconds. The completion of the reactionwas monitored by TLC using ethyl acetate: methanol (4:1) as eluent. The reaction mixture wascooled at room temperature. Cold water (20 mL) was added to it and then extracted withchloroform (3 x 25 mL). The organic layer was dried over anhydrous Na2SO4 and evaporated.Crystallization of the crude product from cyclohexane gave the pure product in 70-80% yields(Table 1).
References:
Pathan, Mohsin Y.;Paike, Vijaykumar V.;Pachmase, Pandurang R.;More, Sandeep P.;Ardhapure, Suresh S.;Pawar, Rajendra P. [ARKIVOC,2006,vol. 2006,# 15,p. 205 - 210]
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