2-Fluoro-1-(2-fluoro-phenyl)-ethanone synthesis
- Product Name:2-Fluoro-1-(2-fluoro-phenyl)-ethanone
- CAS Number:1402412-84-3
- Molecular formula:C8H6F2O
- Molecular Weight:156.13
445-27-2
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1402412-84-3
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$30.00/100mg
Yield:1402412-84-3 89%
Reaction Conditions:
Stage #1: 2'-Fluoroacetophenonewith lithium hexamethyldisilazane in tetrahydrofuran at -74; for 0.666667 h;
Stage #2: with chloro-trimethyl-silane in tetrahydrofuran at -74 - 20;
Stage #3: with Selectfluor in acetonitrile at 4 - 20; for 10.5 h;
References:
Fuchino, Kouki;Mitsuoka, Yasunori;Masui, Moriyasu;Kurose, Noriyuki;Yoshida, Shuhei;Komano, Kazuo;Yamamoto, Takahiko;Ogawa, Masayoshi;Unemura, Chie;Hosono, Motoko;Ito, Hisanori;Sakaguchi, Gaku;Ando, Shigeru;Ohnishi, Shuichi;Kido, Yasuto;Fukushima, Tamio;Miyajima, Hirofumi;Hiroyama, Shuichi;Koyabu, Kiyotaka;Dhuyvetter, Deborah;Borghys, Herman;Gijsen, Harrie J.M.;Yamano, Yoshinori;Iso, Yasuyoshi;Kusakabe, Ken-Ichi [Journal of Medicinal Chemistry,2018,vol. 61,# 12,p. 5122 - 5137] Location in patent:supporting information
218771-68-7
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1402412-84-3
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375-72-4
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73602-61-6
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1402412-84-3
30 suppliers
$30.00/100mg