2-FLUORO-6-METHYLBENZONITRILE synthesis
- Product Name:2-FLUORO-6-METHYLBENZONITRILE
- CAS Number:198633-76-0
- Molecular formula:C8H6FN
- Molecular Weight:135.14
6575-09-3
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198633-76-0
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$12.00/250mg
Yield:198633-76-0 66%
Reaction Conditions:
with cesium fluoride in dimethyl sulfoxide;
Steps:
41 Synthesis of [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-fluoro-6-methylbenzyl)amine
Example 41 Synthesis of [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-fluoro-6-methylbenzyl)amine A mixture of 2-chloro-6-methylbenzonitrile (5 g, 33.0 mmol) and CsF (14 g, 92.2 mmol) in DMSO (30 ml) was heated at 140° C. for 15 hr and then allowed to cool to room temperature. It was diluted with water, extracted with dichloromethane, washed with brine, dried (Na2SO4) and concentrated to give 2-fluoro-6-methylbenzonitrile (2.93 g, 66%).
References:
US6506747,2003,B1
557-21-1
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883502-14-5
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$22.00/1g
198633-76-0
127 suppliers
$12.00/250mg
748101-41-9
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883502-14-5
85 suppliers
$22.00/1g
198633-76-0
127 suppliers
$12.00/250mg