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ChemicalBook CAS DataBase List 2-FLUORO-6-METHYLBENZONITRILE
198633-76-0

2-FLUORO-6-METHYLBENZONITRILE synthesis

3synthesis methods
2-CHLORO-6-METHYLBENZONITRILE

6575-09-3

2-FLUORO-6-METHYLBENZONITRILE

198633-76-0

The general procedure for the synthesis of 2-fluoro-6-methylbenzonitrile from 2-chloro-6-methylbenzonitrile was as follows: a mixture of 2-chloro-6-methylbenzonitrile (5 g, 33.0 mmol) and CsF (14 g, 92.2 mmol) in DMSO (30 ml) was heated and reacted for 15 hours at 140°C. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and subsequently extracted with dichloromethane. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated to give the target product 2-fluoro-6-methylbenzonitrile (2.93 g, 66% yield).

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Yield:198633-76-0 66%

Reaction Conditions:

with cesium fluoride in dimethyl sulfoxide;

Steps:

41 Synthesis of [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-fluoro-6-methylbenzyl)amine

Example 41 Synthesis of [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-fluoro-6-methylbenzyl)amine A mixture of 2-chloro-6-methylbenzonitrile (5 g, 33.0 mmol) and CsF (14 g, 92.2 mmol) in DMSO (30 ml) was heated at 140° C. for 15 hr and then allowed to cool to room temperature. It was diluted with water, extracted with dichloromethane, washed with brine, dried (Na2SO4) and concentrated to give 2-fluoro-6-methylbenzonitrile (2.93 g, 66%).

References:

US6506747,2003,B1

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