2-fluoroMalonaMide synthesis
- Product Name:2-fluoroMalonaMide
- CAS Number:815-59-8
- Molecular formula:C3H5FN2O2
- Molecular Weight:120.08
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Yield:815-59-8 97%
Reaction Conditions:
with ammonia in methanol at 20;Inert atmosphere;
Steps:
Step 1. Preparation of 2-Fluoropropanediamide
To a solution of 1,3-diethyl 2-difluoropropanedioate (25 g, 140.4 mmol) in methanol (100 mL) under a nitrogen atmosphere was added a solution of ammonia in methanol (80 mL, 7 N, 560 mmol).
The resulting mixture was stirred at room temperature overnight and then concentrated in vacuo.
The residue was triturated in petroleum ether to afford 16.3 g of 2-fluoropropanediamide as a white solid (yield was 97%). MS obsd. (ESI+) [(M+H)+] 121.
References:
US2013/90328,2013,A1 Location in patent:Paragraph 0133; 0134
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