ChemicalBook CAS DataBase List 2-HYDROXYDECANOIC ACID

2-HYDROXYDECANOIC ACID synthesis

11synthesis methods

Product Name:2-HYDROXYDECANOIC ACID
CAS Number:5393-81-7
Molecular formula:C10H20O3
Molecular Weight:188.26

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Yield: 60.3%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 100; for 2 h;

Steps:

297.2
The acidic hydrolysis of a nitrile to an acid is described and is referred to as General Method Nitrile Hydrolysis. To a solution of(±)-2-hydroxydecanenitrile (2.0 g, 11.8 mmol) in 1,4-dioxane (10 mL) was added with 36% HC1 solution (10 mL) and the mixture was heated to 100°C while stirring and stirred at the same temperature for 12 h. The volatiles were removed to afford (±)-2-hydroxydecanoic acid (1.6 g, 60.3% yield) as a white solid, which wasused directly for the next step.

References:

RQX PHARMACEUTICALS, INC.;GENENTECH, INC.;CHEN, Yongsheng;SMITH, Peter Andrew;ROBERTS, Tucker Curran;HIGUCHI, Robert I.;PARASELLI, Prasuna;KOEHLER, Michael F. T.;SCHWARZ, Jacob Bradley;CRAWFORD, James John;LY, Cuong Q.;HANAN, Emily J.;HU, Huiyong;YU, Zhiyong WO2017/84630, 2017, A1 Location in patent:Paragraph 00851

334-48-5 Synthesis