2-(hydroxymethyl)-5-methoxypyridin-4-ol synthesis
- Product Name:2-(hydroxymethyl)-5-methoxypyridin-4-ol
- CAS Number:62885-42-1
- Molecular formula:C7H9NO3
- Molecular Weight:155.15
6269-25-6
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$244.00/500mg
62885-42-1
14 suppliers
$133.00/5G
Yield:62885-42-1 75%
Reaction Conditions:
with ammonium hydroxide in methanol;water at 100; for 6 h;Sealed tube;
Steps:
2-(hydroxymethyl)-5-methoxypyridi n-4-oI
To a stirred mixture of 2-(hydroxymethyl)-5-methoxy-4H-pyran-4-one (6.68 g, 42.8 mmcl) inmethanol (10 mL) was added aqueous ammonium hydroxide solution (20 mL, c 25 %, 130mmol). The mixture was heated to 100°C in a sealed tube for 6 h. The solvent was removed in vaccum. Silicagel chromatography gave 4.97 g (75 % yield) of the title compound. LC-MS (Method 5): R = 0.14 mm; MS (ESipos): m/z = 156 [M+H]1H-NMR (400 MHz, DMSO-d6) ? [ppm]: 2.490 (0.83), 2.495 (1.96), 2.499 (2.75), 2.503 (1.80),2.509 (0.83), 3.320 (16.00), 3.643 (1.52), 4.330 (2.40), 4.343 (2.35).
References:
WO2017/102091,2017,A1 Location in patent:Page/Page column 343
501-30-4
667 suppliers
$5.00/25mg
62885-42-1
14 suppliers
$133.00/5G