2-METHOXY-5-METHYLPHENOL synthesis
- Product Name:2-METHOXY-5-METHYLPHENOL
- CAS Number:1195-09-1
- Molecular formula:C8H10O2
- Molecular Weight:138.16
621-59-0
657 suppliers
$9.00/1g
1195-09-1
134 suppliers
$20.00/1g
Yield:1195-09-1 100%
Reaction Conditions:
with hydrazine hydrate;potassium hydroxide at 130 - 190; for 6 h;
Steps:
192.1 Step 1: 2-Methoxy-5-methylphenol
To a suspension of 3-hydroxy-4-methoxybenzaldehyde (5 g, 33 mmol) and KOH (18.4 g, 328 mmol) in ethylene glycol (65 mL) was added hydrazine mono hydrate (9.7 g, 194 mmol). The reaction mixture was heated at 130°C for 1 hr and then at 190°C for 5hr. After cooled down to r.t., the resulting mixture was poured into a mixture of cone. HCI (42 mL) and ice water (150 mL) and extracted with ether. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated under reduced pressure to give the title compound (4.8 g, quant, yield) as a white solid. LCMS (ES+) (m/z): 139.0 (M+1). 1H NMR (400 MHz, CDC ) δ 6.79 - 6.71 (m, 2H), 6.67 - 6.61 (m, 1 H), 5.56 (s, 1 H), 3.85 (s, 3H), 2.26 (s, 3H).
References:
VIIV HEALTHCARE UK LIMITED;VELTHUISEN, Emile Johann;WEATHERHEAD, Jason Gordon WO2018/20357, 2018, A1 Location in patent:Page/Page column 97
104-93-8
409 suppliers
$6.00/25g
1195-09-1
134 suppliers
$20.00/1g
20734-74-1
57 suppliers
$13.00/100mg
494-99-5
197 suppliers
$12.00/25g
1195-09-1
134 suppliers
$20.00/1g
93-51-6
396 suppliers
$15.00/5g
452-86-8
339 suppliers
$5.00/5g
104-93-8
409 suppliers
$6.00/25g
1195-09-1
134 suppliers
$20.00/1g
