2-methyl-1-phenylpiperazine synthesis

Yield:2946-76-1 100%

Reaction Conditions:

with hydrogen;10% palladium on activated carbon in methanol at 20; for 21 h;

Steps:

32 EXAMPLE 32

1-(4-chlorophenyl)-2-methylpiperazine (300 mg, 1.4 mmol) was dissolved in methanol (3 ml), and the resulting solution was mixed with palladium carbon (150 mg) and stirred at a room temperature for 21 hours in an atmosphere of hydrogen. The reaction solution was filtered, and the thus obtained residue was thoroughly washed with ethanol. The washed solution and filtrate were combined, and the solvent was evaporated therefrom under a reduced pressure to obtain 260 mg of the title compound (1.4 mmol, 100% in yield). 1H-NMR (CDCl3) δ 1.11 (1 H, d, J=6.5 Hz), 3.06-3.12 (1 H, m), 3.30-3.46 (5 H, m), 3.78-3.85 (1 H, m), 7.01-7.09 (3 H, m), 7.29-7.34 (2 H, m); MW 176.26 (C11H16N2); Mass spectrum EI m/z 176 (M)+

References:

US6355642,2002,B1 Location in patent:Page column 23