(2-Methyl-1H-indol-4-yl)methanamine synthesis
- Product Name:(2-Methyl-1H-indol-4-yl)methanamine
- CAS Number:1360883-23-3
- Molecular formula:C10H12N2
- Molecular Weight:160.22
1360883-22-2
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Yield:1360883-23-3 95.1%
Reaction Conditions:
with ammonia;hydrogen in methanol at 20; for 3 h;
Steps:
15.5
step 5: To a solution of 2-methyl- lH-indole-4-carbonitrile (408 mg, 2.61 mmol) in NH3/MeOH (7 M, 20 mL) was added Raney nickel (100 mg). The mixture was stirred under hydrogen at latmosphere at RT for 3 h. The mixture was filtered with Celite and the filtrate was concentrated in vacuo to afford (2-methyl- lH-indol-4-yl)methanamine (105) as a yellow solid (398 mg, 95.1%). MS (ESI): m/z =144.3 [M-16]+.
References:
WO2013/26914,2013,A1 Location in patent:Page/Page column 110
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6127-18-0
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