2-Methyl-2,3-dihydro-4H-1-benzopyran-4-one synthesis

8synthesis methods

Product Name:2-Methyl-2,3-dihydro-4H-1-benzopyran-4-one
CAS Number:5631-75-4
Molecular formula:C10H10O2
Molecular Weight:162.19

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2-Methyl-2,3-dihydro-4H-1-benzopyran-4-one

5631-75-4
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Yield:5631-75-4 76.9%

Reaction Conditions:

with sulfuric acid;acetic acid at 20; for 4 h;Reflux;

Steps:

1.2 (2) Preparation of Compound 6:

Compound 7 (6.95 g, 38.9 mmol) was dissolved in 70 mL of glacial acetic acid.4.6 mL of concentrated sulfuric acid was slowly added dropwise with stirring at room temperature.Heated to reflux for 4 hours, and poured the reaction solution into ice water.Adjust the pH of the solution to 7 with saturated sodium carbonate.Extract three times with dichloromethane, retain the organic phase,Dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give compound 6, yield 76.9%.

References:

CN109666012,2019,A Location in patent:Paragraph 0032; 0043; 0046