2-methyl-2-phenylpropanal synthesis
- Product Name:2-methyl-2-phenylpropanal
- CAS Number:3805-10-5
- Molecular formula:C10H12O
- Molecular Weight:148.2
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Yield: 91.6%
Reaction Conditions:
with sulfur trioxide pyridine complex;triethylamine in dimethyl sulfoxide at 20; for 2.5 h;
Steps:
82
To a solution of 2-methyl-2-phenyl-propan-1-ol (13.3 g, 87.0 mmol) in DMSO (150 mL) was added triethylamine (24.7 mL, 178.0 mmo) at rt, followed by pyridine sulfuric oxide (28.6 g, 180.0 mmol). The mixture was stirred for 2.5 h at rt. Water was added and the resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated to obtain the crude product 2-methyl-2-phenyl- propionaldehyde (12.0 mg, 91.6 %), which was used to the next step without further purification.
References:
NOVO NORDISK A/S WO2008/84044, 2008, A1 Location in patent:Page/Page column 117
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