2-METHYL-5-NITROPHENYL ACETATE synthesis
- Product Name:2-METHYL-5-NITROPHENYL ACETATE
- CAS Number:54362-24-2
- Molecular formula:C9H9NO4
- Molecular Weight:195.17
Yield:54362-24-2 100%
Reaction Conditions:
with sodium hydroxide in water at 20; for 0.666667 h;
Steps:
17
The starting material was prepared as follows: To a mixture of 2-methyl-5-nitrophenol (2.5 g, 16.3 mmol) and 1M aqueous sodium hydroxide (24.5 ml) at ambient temperature was added acetic anhydride (1.9 ml 120.3 mmol).. The mixture was stirred for 40 minutes, the solid was removed by filtration and the filtrate was extracted with ethyl acetate.. The organic layers were combined, washed with an aqueous saturated sodium chloride solution, dried (MgSO4) and the volatiles were removed by evaporation to yield 2-acetoxy-4-nitrotoluene (3.1 g, 100%).. A mixture of this material (3.1 g, 15.9 mmol) and 10% palladium-on-charcoal catalyst (0.12 g) in ethyl acetate (50 ml) was stirred at ambient temperature under hydrogen for 2 hours.. The catalyst was removed by filtration and the volatiles were removed by evaporation to give 3-acetoxy-4-methylaniline (2.45 g, 94%).
References:
Zeneca Limited;Zeneca Pharma S.A. US6809097, 2004, B1 Location in patent:Page column 50
5428-54-6
302 suppliers
$8.00/10g
54362-24-2
10 suppliers
inquiry
99-55-8
426 suppliers
$6.00/25g
54362-24-2
10 suppliers
inquiry
5428-54-6
302 suppliers
$8.00/10g
127-09-3
1110 suppliers
$8.00/1 ea
54362-24-2
10 suppliers
inquiry