2-Morpholinemethanol, α-phenyl-, (αR,2R)- synthesis
- Product Name:2-Morpholinemethanol, α-phenyl-, (αR,2R)-
- CAS Number:1190855-57-2
- Molecular formula:C11H15NO2
- Molecular Weight:193.25
611-71-2
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Yield:-
Steps:
Multi-step reaction with 8 steps
1.1: acetyl chloride / 20 °C
1.2: 5 h / 40 °C
2.1: diisobutylaluminium hydride / dichloromethane; hexane / 10 h / -78 °C / Inert atmosphere
3.1: (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; copper(II) acetate monohydrate / 72 h / 20 °C
4.1: hydrogenchloride / methanol; water / 20 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr
6.1: potassium carbonate / 1 h / 0 °C
7.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux
References:
Liu, Cheng;Lin, Zhi-Wei;Zhou, Zhao-Hui;Chen, Hong-Bin [Organic and Biomolecular Chemistry,2017,vol. 15,# 25,p. 5395 - 5401]
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