2-Naphthalenecarboxaldehyde,6-ethoxy-(9CI) synthesis
- Product Name:2-Naphthalenecarboxaldehyde,6-ethoxy-(9CI)
- CAS Number:757230-55-0
- Molecular formula:C13H12O2
- Molecular Weight:200.23
78119-82-1
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$20.00/1g
75-03-6
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$11.00/5g
757230-55-0
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$412.00/1g
Yield:757230-55-0 88%
Reaction Conditions:
with potassium carbonate in acetone;Reflux;
Steps:
6-Ethoxy-2-naphthaldehyde (2i)
General procedure: The mixture of hydroxy-naphtalene-carboxaldehyde (1 equiv.),K2CO3 (1.5 equiv.) and alkyl halide (1.5 equiv.) in acetone (12 mL/mmol) was stirred under reflux for 4e24 h. When TLC showedcomplete disappearance of the starting materials, solvent wasevaporated under reduced pressure. The residue was purified bycolumn chromatography on silica gel (cyclohexane/EtOAc 90:10 to 70:30)
References:
Manzano, José Ignacio;Cochet, Florent;Boucherle, Benjamin;Gómez-Pérez, Verónica;Boumendjel, Ahcène;Gamarro, Francisco;Peuchmaur, Marine [European Journal of Medicinal Chemistry,2016,vol. 123,p. 161 - 170]
74-96-4
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78119-82-1
187 suppliers
$20.00/1g
757230-55-0
19 suppliers
$412.00/1g
15231-91-1
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$7.00/5g
757230-55-0
19 suppliers
$412.00/1g
1092788-34-5
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757230-55-0
19 suppliers
$412.00/1g