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ChemicalBook CAS DataBase List 2-Oxa-spiro[3.3]heptan-6-one

2-Oxa-spiro[3.3]heptan-6-one synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: -20 - 15 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere
2.2: 12 h / -78 - 20 °C / Inert atmosphere

References: