2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID synthesis
- Product Name:2-PHENYL-5-METHYL-1,3-DIOXANE-5-CARBOXYLIC ACID
- CAS Number:207850-04-2
- Molecular formula:C12H14O4
- Molecular Weight:222.24
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207850-04-2
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Yield:207850-04-2 82.3%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene; for 8 h;Reflux;
Steps:
1.1 EXAMPLE 1
[0028] 1) To a 100 mL single-mouth bottle 0.80 g (5 9 mmol) of 2,2-dimethylol propionic acid, 0.63 g (5.9 mmol) of benzaldehyde, 0.1 g of p-toluenesulfonic acid, and 40 mL of toluene were added to form a solution. The solution was then heated and refluxed for 8 h. Thereafter, the solution was cooled to room temperature and a product precipitated in a decompression condition. 30 mL of saturated sodium carbonate aqueous solution was added to the solution to from a mixture. After being stirred for 20 min, the mixture was transferred to a separating funnel, and was extracted by using 30 mL×3 of ether whereby separating an aqueous phase from an organic phase. A 2 N sulfuric acid was then added to the aqueous phase to neutralize the pH value thereof. Finally, the aqueous phase was filtrated and dried to a constant weight to yield intermediate II-1, the formula of which is as follows. 1.09 g of the intermediate II-1 was obtained, and the yield thereof was 82.3%.
References:
US2013/296572,2013,A1 Location in patent:Paragraph 0028
4767-03-7
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207850-04-2
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$374.00/500mg
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207850-04-2
13 suppliers
$374.00/500mg