(2-PHENYL-IMIDAZOL-1-YL)-ACETIC ACID synthesis

Yield:842958-44-5 67%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon at 20; for 14 h;

Steps:

46

To a stirred solution of (2-phenylimidazol-1-yl)acetic acid benzyl ester (1.2 g, 4.1 mmol) in methanol (30 mL) was added 10% palladium on carbon (130 mg). The resultant reaction mixture was subjected to hydrogenation using a balloon full of hydrogen at room temperature for 14 h. This was filtered through a pad of Celite, the Celite pad was washed with methanol, and the combined filtrate was concentrated to get (2-phenylimidazol-1-yl)acetic acid (0.56 g, 67% yield). NMR (300 MHz, DMSO-d₆): δ 7.42-7.55 (m, 5H), 7.29 (, J=1.37 Hz, 1H), 7.01 (d, J=1.37 Hz, 1H), 4.85 (s, 2H).

References:

US2006/211603,2006,A1 Location in patent:Page/Page column 58