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2-(PHENYLTHIO)NICOTINONITRILE synthesis

1synthesis methods
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Yield:35620-68-9 97%

Reaction Conditions:

Stage #1: thiophenolwith sodium hydride in N,N-dimethyl-formamide;mineral oil at 25; for 1 h;Inert atmosphere;
Stage #2: 2-chloro-3-pyridinecarbonitrile in N,N-dimethyl-formamide;mineral oil at 25; for 16 h;Inert atmosphere;

References:

Melzig, Laurin;Metzger, Albrecht;Knochel, Paul [Chemistry - A European Journal,2011,vol. 17,# 10,p. 2948 - 2956] Location in patent:supporting information; experimental part