2-Propyn-1-ol, 3-(3-chloro-2-methylphenyl)- synthesis
1synthesis methods
- Product Name:2-Propyn-1-ol, 3-(3-chloro-2-methylphenyl)-
- CAS Number:1093172-97-4
- Molecular formula:C10H9ClO
- Molecular Weight:180.63
Yield:1093172-97-4 99%
Reaction Conditions:
Stage #1: 2-chloro-6-iodotoluene;propargyl alcoholwith trans-bis(triphenylphosphine)palladium dichloride;diethylamine at 20; for 0.25 h;Inert atmosphere;Sonogashira Cross-Coupling;
Stage #2: with copper(l) iodide at 50; for 3 h;Inert atmosphere;
References:
Dell'Acqua, Monica;Pirovano, Valentina;Confalonieri, Giorgio;Arcadi, Antonio;Rossi, Elisabetta;Abbiati, Giorgio [Organic and Biomolecular Chemistry,2014,vol. 12,# 40,p. 8019 - 8030]