2-((pyridin-3-yl)Methyl)hydrazine hydrochloride synthesis
- Product Name:2-((pyridin-3-yl)Methyl)hydrazine hydrochloride
- CAS Number:57616-01-0
- Molecular formula:C6H10ClN3
- Molecular Weight:159.6167
348628-13-7
4 suppliers
inquiry
57616-01-0
22 suppliers
inquiry
Yield:57616-01-0 96%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 5 - 20; for 72 h;
Steps:
71.7 Step-7:
Synthesis of 3-(hydrazinylmethyl)pyridine hydrochloride (Compound C)
To a solution of Compound B (70 g, 313 mmol) in 1,4-dioxane (350 mL) was added 4N HCl in dioxane (1 L) at 5°C, and the mixture was stirred at room temperature for 72 hours.
After the reaction completed, the reaction mixture was concentrated under reduced pressure to obtain Compound C (48 g).
Yield: 96%, 1H NMR (400 MHz, DMSO-d6) δ 4.32 (s, 2H), 8.11 (dd, J=8.07, 5.62 Hz, 1H), 8.33-8.42 (m, 2H), 8.67 (d, J=7.82 Hz, 1H), 8.91 (d, J=5.87 Hz, 1H), 8.97 (s, 1H) and LC-MS:
No mass ionization.
References:
EP3640253,2020,A1 Location in patent:Paragraph 0363; 0376-0377
500-22-1
510 suppliers
$6.00/5g
57616-01-0
22 suppliers
inquiry
392740-65-7
0 suppliers
inquiry
57616-01-0
22 suppliers
inquiry