
2-PYRIDINECARBOXAMIDE, 5-HYDROXY- synthesis
- Product Name:2-PYRIDINECARBOXAMIDE, 5-HYDROXY-
- CAS Number:896419-97-9
- Molecular formula:C6H6N2O2
- Molecular Weight:138.12

15069-92-8
263 suppliers
$20.00/5g

896419-97-9
28 suppliers
$180.00/100mg
Yield: 7%
Reaction Conditions:
with ammonium chloride;N-ethyl-N,N-diisopropylamine;HATU in N,N-dimethyl-formamide at 20;
Steps:
vii (vii) 5-Hydroxypicolinamide (111 )
A suspension of 5-hydroxypicolinic acid (1 g, 7.2 mmol), NhUCI (3.8 g, 72 mmol), HATU (3.3 g, 8.64 mmol) and DIPEA (2.8 g, 21 .6 mmol) in DMF (20 ml.) was stirred at room temperature overnight. Water (100 ml.) was added and the mixture was extracted with EtOAc (50 ml. x 3). The combined organic extracts were washed with brine (100 ml_), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give the title product (65 mg, 7%) as a white solid. LCMS-C: rt 0.98 min, m/z 139.1 [M+H]+.
References:
CTXT PTY LIMITED;MORROW, Benjamin, Joseph;CAMERINO, Michelle, Ang;WALKER, Scott, Raymond;STEVENSON, Graeme, Irvine;STUPPLE, Paul, Anthony WO2019/219820, 2019, A1 Location in patent:Page/Page column 105