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2-Quinoxalineacetonitrile synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C
1.2: 20 °C
2.1: trifluoroacetic acid / dichloromethane / 10 h / 20 °C / Inert atmosphere

References:

Zhang, Qisong;Yu, Peng;Fan, Yong;Sun, Caixia;He, Haisheng;Liu, Xuan;Lu, Lingfei;Zhao, Mengyao;Zhang, Hongxin;Zhang, Fan [Angewandte Chemie - International Edition,2021,vol. 60,# 8,p. 3967 - 3973][Angew. Chem.,2021,vol. 133,# 8,p. 4013 - 4019,7]