2-(tert-Butyl)-4-chloro-5-nitropyriMidine synthesis
- Product Name:2-(tert-Butyl)-4-chloro-5-nitropyriMidine
- CAS Number:70227-50-8
- Molecular formula:C8H10ClN3O2
- Molecular Weight:215.64
70227-49-5
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Yield:70227-50-8 92%
Reaction Conditions:
with trichlorophosphate for 5 h;Heating / reflux;
Steps:
O
Synthesis of Compound O.5. A solution of compound O.4 (12 g, 60.9 mmol) in phosphorus oxychloride (96 mL) was stirred at reflux for 5 hr. The reaction mixture was cooled to RT and the excess phosphorus oxychloride was concentrated in vacuo. The residue was added to ice-water and extracted into DCM. The organic layer was dried (Na2SO4) and removed in vacuo to afford compound O.5, 2-tert-butyl-4-chloro-5-nitropyrimidine, as a brown liquid (12 g, 92%) which was used without further purification.
References:
US2009/5359,2009,A1 Location in patent:Page/Page column 45
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