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2-[[(Tetrahydropyran-2-yl)oxy]Methyl]benzaldehyde synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: 90 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran / -78 - 0 °C
2.2: 92 percent / tetrahydrofuran / -78 - 20 °C

References:

Bentley, David J;Fairhurst, John;Gallagher, Peter T;Manteuffel, Astrid K;Moody, Christopher J;Pinder, Joanne L [Organic and biomolecular chemistry,2004,vol. 2,# 5,p. 701 - 708]