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2-Thiophenecarboxamide,3-amino-N-methyl-(9CI) synthesis

5synthesis methods
22288-78-4 Synthesis
Methyl 3-amino-2-thiophenecarboxylate

22288-78-4
386 suppliers
$11.00/5g

-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: dmap / dichloromethane / 3 h / 0 - 40 °C
1.2: 1 h
2.1: sodium hydroxide; water / tetrahydrofuran / 12 h / 70 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16.17 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

References:

CN114213400,2022,A