(R)-TERT-BUTYL 4-(2-HYDROXYETHYL)-2,2-DIMETHYLOXAZOLIDINE-3-CARBOXYLATE synthesis
- Product Name:(R)-TERT-BUTYL 4-(2-HYDROXYETHYL)-2,2-DIMETHYLOXAZOLIDINE-3-CARBOXYLATE
- CAS Number:201404-86-6
- Molecular formula:C12H23NO4
- Molecular Weight:245.32
77-76-9
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397246-14-9
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$60.00/500mg
201404-86-6
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$1133.00/5g
Yield:201404-86-6 98%
Reaction Conditions:
with toluene-4-sulfonamide in dichloromethane at 20; for 3 h;Concentration;
Steps:
1
The compound of formula 5 (2.05 g 10 mmol) was dissolved in anhydrous dichloromethane (20 ml).2,2-dimethoxypropane (1.04 g 10 mmol) and a catalytic amount of p-toluenesulfonamide were added to the above solution, and the solution system was stirred at room temperature. After 3 hours, the solvent was evaporated to obtain a crude oily substance, which was passed through the column. Chromatographic separation, using a certain ratio of EA / hexane, to obtain 2.4g of the compound shown in Formula 6, the property of a colorless oil, the yield of 98%.
References:
CN105017081,2017,B Location in patent:Paragraph 0065; 0066; 0067; 0076; 0084
115378-31-9
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$91.00/100mg
201404-86-6
24 suppliers
$1133.00/5g
428440-11-3
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201404-86-6
24 suppliers
$1133.00/5g