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Bicyclo[3.1.1]heptane-2,3-diol, 2,6,6-trimethyl-, [1R-(1α,2β,3β,5α)]- (9CI) synthesis

3synthesis methods
-

Yield:20536-51-0 96.5%

Reaction Conditions:

with pyridine;osmium(VIII) oxide;trimethylamine-N-oxide in water;tert-butyl alcohol; for 24 h;Reflux;

References:

Zhu, Yongqiang;Wu, Gang;Zhu, Xinrong;Ma, Yuheng;Zhao, Xin;Li, Yuejie;Yuan, Yunxia;Yang, Jie;Yu, Sen;Shao, Feng;Lei, Meng [Journal of Medicinal Chemistry,2010,vol. 53,# 24,p. 8619 - 8626] Location in patent:supporting information; experimental part