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209917-93-1

1-(3-cyanophenyl)-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid synthesis

8synthesis methods
3-(5-(hydroxyMethyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl)benzonitrile

209919-64-2
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1-(3-cyanophenyl)-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid

209917-93-1
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Yield:209917-93-1 89.9%

Reaction Conditions:

with ruthenium trichloride;sodium periodate in acetonitrile at 20; for 18 h;

References:

Pinto;Orwat;Wang;Fevig;Quan;Amparo;Cacciola;Rossi;Alexander;Smallwood;Luettgen;Liang;Aungst;Wright;Knabb;Wong;Wexler;Lam [Journal of Medicinal Chemistry,2001,vol. 44,# 4,p. 566 - 578]