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ChemicalBook CAS DataBase List (1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID
214193-13-2

(1S,3S,5S)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: PPTS
2: NH4Cl / 150 °C / 20 - 100 Torr
3: 65 percent / Et2Zn / 1,2-dichloro-ethane; hexane / a) 0 deg C, 30 min, b) RT, 6 h
4: DMAP, Et3N / CH2Cl2
5: 1.) aq. LiOH, 2.) HCO2H / 1.) MeOH

References:

Hanessian, Stephen;Reinhold, Ulrich;Saulnier, Michel;Claridge, Stephen [Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,# 16,p. 2123 - 2128]