ChemicalBook CAS DataBase List 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine

3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine synthesis

2synthesis methods

Product Name:3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine
CAS Number:215874-86-5
Molecular formula:C17H14N8O2
Molecular Weight:362.35

77177-21-0
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215874-89-8 Synthesis

1,2,4-Triazolo[3,4-a]phthalazine, 6-chloro-3-(5-Methyl-3-isoxazolyl)-

215874-89-8
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3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy][1,2,4]triazolo[3,4-a]phthalazine

215874-86-5
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$140.00/5mg

Yield:215874-86-5 61%

Reaction Conditions:

Stage #1: (1-methyl-1H-[1,2,3]triazol-4-yl)methanolwith lithium hexamethyldisilazane in tetrahydrofuran;N,N-dimethyl-formamide at -10; for 0.5 h;
Stage #2: 6-chloro-3-(5-methylisoxazol-3-yl)-1,2,4-triazolo[3,4-a]phthalazine in tetrahydrofuran;N,N-dimethyl-formamide at 20; for 16 h;

References:

Sternfeld, Francine;Carling, Robert W.;Jelley, Richard A.;Ladduwahetty, Tamara;Merchant, Kevin J.;Moore, Kevin W.;Reeve, Austin J.;Street, Leslie J.;O'Connor, Desmond;Sohal, Bindi;Atack, John R.;Cook, Susan;Seabrook, Guy;Wafford, Keith;Tattersall, F. David;Collinson, Neil;Dawson, Gerard R.;Castro, José L.;MacLeod, Angus M. [Journal of Medicinal Chemistry,2004,vol. 47,# 9,p. 2176 - 2179]

3-Isoxazolecarboxylic acid, 5-methyl-, 2-(4-chloro-1-phthalazinyl)hydrazide

215874-90-1
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215874-86-5
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$140.00/5mg

References