2-PHENYL-5-(3-PYRIDINYL)-2,4-DIHYDRO-3H-PYRAZOL-3-ONE synthesis

Yield:-

Reaction Conditions:

with phenylhydrazine in ethanol;

Steps:

S.1 Synthesis of 1-phenyl-3-(3-pyridyl)-2-pyrazolin-5-one (Compound No. 1)

Synthesis Example 1 Synthesis of 1-phenyl-3-(3-pyridyl)-2-pyrazolin-5-one (Compound No. 1) To 15 ml of ethanol were added by 3.86 g of ethyl 3-oxo-3-(3-pyridyl) propionate and 2.16 g of phenylhydrazine and stirred for 2 hours at 50° to 60° C. After allowing to cool, the deposited crystals were filtrated off and recrystallized from ethanol to obtain 2.83 g of Compound No. 1 as colorless crystals.

References:

US4906644,1990,A