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ChemicalBook CAS DataBase List Methyl 1-chloro-4-hydroxyisoquinoline-3-carboxylate
223388-20-3

Methyl 1-chloro-4-hydroxyisoquinoline-3-carboxylate synthesis

3synthesis methods
13972-97-9 Synthesis
3-Isoquinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-oxo-, Methyl ester

13972-97-9
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Yield:223388-20-3 98%

Reaction Conditions:

with trichlorophosphate at 80; for 2 h;

References:

Stubbs, Christopher J.;Loenarz, Christoph;Mecinovi?, Jasmin;Kar, Kheng Yeoh;Hindley, Nicola;Liénard, Beno?t M.;Sobott, Frank;Schofield, Christopher J.;Flashman, Emily [Journal of Medicinal Chemistry,2009,vol. 52,# 9,p. 2799 - 2805] Location in patent:supporting information; experimental part