6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE OXIME synthesis

2synthesis methods

Product Name:6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE OXIME
CAS Number:23576-85-4
Molecular formula:C6H4ClN3OS
Molecular Weight:201.63

6-CHLOROIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

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6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE OXIME

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Yield:-

Reaction Conditions:

with ammonium hydroxide;hydroxylamine hydrochloride in ethanol;water; pH=6; for 0.166667 h;Reflux;

Steps:

3.1.3. Synthesis of the Oximes 3a and 3b

General procedure: The appropriate aldehyde 2a or 2b (14 mmol) was dissolved in 50 mL of ethanol and treated with a solution of hydroxylamine hydrochloride (14.4 mmol) in 10 mL of water. In order to avoid the precipitation of the oxime as hydrochloride, the solution was treated with a few drops of 32% NH4OH (pH=6). The mixture was refluxed for 10 min. and,after cooling, the crude oxime was recovered by filtrationand crystallized from xylene (3a) or EtOH (3b).

References:

Morigi, Rita;Vitali, Beatrice;Prata, Cecilia;Palomino, Rogers A. ?.;Graziadio, Alessandra;Locatelli, Alessandra;Rambald, Mirella;Leoni, Alberto [Medicinal Chemistry,2018,vol. 14,# 3,p. 311 - 319]

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References