2-Quinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo- synthesis

3synthesis methods

Product Name:2-Quinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-
CAS Number:238755-39-0
Molecular formula:C10H9NO3
Molecular Weight:191.18

238755-38-9 Synthesis

2-Quinolinecarboxaldehyde,5,6,7,8-tetrahydro-8-oxo-(9CI)

238755-38-9
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2-Quinolinecarboxylic acid, 5,6,7,8-tetrahydro-8-oxo-

238755-39-0
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Yield:238755-39-0 93%

Reaction Conditions:

with formic acid;dihydrogen peroxide in water;

Steps:

1 6,7-Dihydro-8(5H)-quinolinone-2-carboxylic acid (5)

6,7-Dihydro-8(5H)-quinolinone-2-carboxylic acid (5) To a 500 mL Erlenmeyer flask equipped with a stirring bar were added 6,7-dihydro-8(5H)-quinolinone-2-carboxaldehyde (4, 15.0 g, 85.6 mmol) and formic acid (17.0 g, 0.3 70 mmol). The mixture was stirred until clear solution was formed. Then 30% H₂O₂ aqueous solution (28.0 g) was added dropwise at 0° C. over a period of 10 mm. After the solid was formed, water (50 mL) was added and the resulting mixture was refrigerated overnight. The white precipitate was collected by vacuum filtration, washed with ice cold water and dried in vacuo to give carboxylic acid 5 (15.2 g, 93%). Physical data see A. B. Khasanov's Ph. D. Thesis (2000).

References:

US2002/81626,2002,A1

91-63-4 Synthesis

91-63-4
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$23.00/25g

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References

2617-98-3 Synthesis

2617-98-3
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$14.00/250mg

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References