1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazole-5-sulfonyl chloride(SALTDATA: FREE) synthesis

Yield:24134-65-4 88%

Reaction Conditions:

with chlorosulfonic acid at 20; for 5 h;

Steps:

1.5 (5) Synthesis of 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo [d] imidazole-5-sulfonyl chloride

Take 1,3-dimethyl-1,3-dihydro-2H-benzo [d] imidazol-2-one (1.0 g, 6.1 mmol),Add to chlorosulfonic acid and react at room temperature for 5 hours;After the reaction is completed, water is added to precipitate a solid, which is filtered with suction, recrystallized, and filtered with suction, and the filter cake is dried under infrared.A gray solid was obtained with a yield of 88%.

References:

CN110776494,2020,A Location in patent:Paragraph 0049; 0055; 0064-0065