5-methyl-1-(2-pyridinyl)-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE) synthesis
- Product Name:5-methyl-1-(2-pyridinyl)-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE)
- CAS Number:241798-60-7
- Molecular formula:C10H9N3O2
- Molecular Weight:203.2
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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241798-60-7
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Yield: 23 mg
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in water;N,N-dimethyl-formamide at 20; for 0.5 h;
Steps:
5-methyl-1- (pyridin-2-yl) -1H- pyrazole-4-carboxylic acid
Note that described in Example 15 1- (5-bromo-2-yl) -5-methyl -1H- pyrazole-4-carboxylic acid N, N- dimethylformamide (1) of (30mg) 10% palladium-carbon (50% water content) at room temperature, the solution was added (10mg) and stirred 30 minutes at the same temperature under a hydrogen atmosphere. After completion of the reaction, distilling off the solvent under reduced pressure after filtering the reaction solution with Celite, and by carrying out the azeotropic concentration with toluene to obtain the title compound (23mg) as a white solid.
References:
Mitsubishi Tanabe Pharma Corporation;Watanabe, Masayuki;Furukawa, Hiroyuki;Hamada, Maiko;Fuji, Naoto;Ushio, Hiroyuki;Takashima, Toru KR2015/2661, 2015, A Location in patent:Paragraph 0373; 0374
1000210-73-0
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241798-60-7
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4930-98-7
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241798-60-7
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3788-94-1
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241798-60-7
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766-11-0
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241798-60-7
16 suppliers
$98.00/1 g