(3aS,6aR)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione synthesis
- Product Name:(3aS,6aR)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione
- CAS Number:28092-62-8
- Molecular formula:C19H18N2O3
- Molecular Weight:322.36
157378-76-2
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28092-62-8
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Yield:28092-62-8 98%
Reaction Conditions:
with hydrogenchloride in water at 90; for 1 h;Reagent/catalyst;
Steps:
15-20 Example 15: Preparation of Compound I
mpound IV (10 g, 29.4 mmol) was added to 40 ml of a 4M hydrochloric acid solution and stirred at 90 ° C for one hour.Filtration, washing with water (50 ml), and the filter cake was dried in vacuo to give the lactone compound I 9.27 g, 98%.The chiral purity was 98.5% ee (HPLC).
References:
CN109748924,2019,A Location in patent:Paragraph 0021; 0081-0092
![(cis)-1,3-dibenzyldihydro-1H-furo[3,4-d]imidazole-2,4,6(3H)-trione](/CAS/GIF/26339-42-4.gif)
26339-42-4
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28092-62-8
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83889-77-4
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![1H-Furo[3,4-d]imidazole-2,4-dione, tetrahydro-1,3-bis(phenylmethyl)-, (3aR,6aS)-](/CAS/20200611/GIF/87585-00-0.gif)
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