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5-PHENYL-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID synthesis

2synthesis methods
-

Yield:294194-47-1 65%

Reaction Conditions:

Stage #1: C16H12F3N3O2with sodium hydroxide in ethanol;water at 65; for 4 h;
Stage #2: with hydrogenchloride at 20; pH=1;

References:

Mulakayala, Naveen;Reddy, Upendar;Chaitanya;Hussain, Manzoor;Kumar, Chitta Suresh;Golla, Narayanaswamy [Journal of the Korean Chemical Society,2011,vol. 55,# 4,p. 719 - 722] Location in patent:experimental part