(2E)-3-(2-Fluoro-3-Methoxyphenyl)-2-Propenoic Acid synthesis

Yield:630423-29-9 61%

Steps:

1 Step 1

Step 1
Modifications:
3.92 g (E)-3-(2-fluoro-3-methoxyphenyl)acrylic acid was used instead of (E)-3-(4-fluoro-2-methoxyphenyl)acrylic acid which gave 5-fluoro-6-methoxyisoquinolin-1-ol (2.4 g, 61% yield).
¹H NMR (400 MHz, CD₃OD) δ ppm 8.09 (d, J=8.80 Hz, 1H), 7.35 (t, J=8.44 Hz, 1H), 7.16 (d, J=7.34 Hz, 1H), 6.72 (m, 1H), 4.00 (s, 3H).

References:

US2013/115190,2013,A1 Location in patent:Page/Page column