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(2E,7R,11S)-Vitamin K1 synthesis

11synthesis methods
Naphthalene, 1,4-dimethoxy-2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,S*-(E)]]- (9CI)

132437-86-6
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(2E,7R,11S)-Vitamin K1

132487-93-5
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Yield:132487-93-5 81%

Reaction Conditions:

with ammonium cerium(IV) nitrate in water;acetonitrile;benzene at 0;

References:

Schmid;Antoulas;Ruttinmann;Schmid;Vecchi Weiser [Helvetica Chimica Acta,1990,vol. 73,# 5,p. 1276 - 1299]