2H-1,4-Benzoxazin-3(4H)-one, 8-(1-piperazinyl)- synthesis
- Product Name:2H-1,4-Benzoxazin-3(4H)-one, 8-(1-piperazinyl)-
- CAS Number:105685-36-7
- Molecular formula:C12H15N3O2
- Molecular Weight:233.27
321126-82-3
37 suppliers
$80.00/250mg
821-48-7
567 suppliers
$6.00/25g
105685-36-7
2 suppliers
inquiry
Yield:105685-36-7 64%
Reaction Conditions:
in chlorobenzene; for 100 h;Reflux;
Steps:
38
Intermediate 59:[0209] To a solution of intermediate 58 (164 mg, 1.0 mmol) in chlorobenzene (5 mL) was added bis(2-chloroethyl)amine hydrochloric acid (285 mg, 1.6 mmol) and the mixture was heated to reflux for 100 h. The reaction mixture was concentrated in vacuo and the residue was stirred in EtOAc for 2 h. The resulting brown solid was filtered and purified by silica gel chromatography to give 8-(piperazin-l-yl)-2H-benzo[b][l,4] oxazin-3(4H)-one (intermediate 59) (150 mg, 64%). HPLC: 99%, RT 1.344 min. MS(ESI) m/z 234.1 [M + H]+.
References:
WO2012/3418,2012,A2 Location in patent:Page/Page column 94
![6-CHLORO-8-NITRO-4H-BENZO[1,4]OXAZIN-3-ONE](/CAS/GIF/870064-73-6.gif)
870064-73-6
35 suppliers
$85.00/100mg
105685-36-7
2 suppliers
inquiry
908863-01-4
0 suppliers
inquiry
105685-36-7
2 suppliers
inquiry
35588-38-6
11 suppliers
$60.00/100mg
105685-36-7
2 suppliers
inquiry
95-85-2
405 suppliers
$13.00/25g
105685-36-7
2 suppliers
inquiry