2H-Benzimidazol-2-one,1,3-dihydro-5-hydroxy-(9CI) synthesis
- Product Name:2H-Benzimidazol-2-one,1,3-dihydro-5-hydroxy-(9CI)
- CAS Number:39513-24-1
- Molecular formula:C7H6N2O2
- Molecular Weight:150.13
2080-75-3
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39513-24-1
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Yield:39513-24-1 94%
Reaction Conditions:
with boron tribromide in dichloromethane at 0 - 40; for 8 h;
Steps:
15.2 Step2: Synthesis of I15-3:
To a solution of compoundI15-2 (2 g, 12.20 mmol) in DCM (40 mL) was added BBr 3 (15 g, 59.88 mmol) dropwise at 0 . The reaction mixture was stirred at 40 for 8 hours, adjusted pH to 8 with Na 2CO 3 and concentrated. The product was dissolved out by THF, filtered and concentrated to afford compound I15-3 (1.7 g, 94%yield) as a brown solid. MS Calcd.: 150; MS Found: 151 [M+H] +.
References:
WO2020/169069,2020,A1 Location in patent:Page/Page column 62
102-51-2
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96-96-8
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39513-24-1
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213118-56-0
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