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ChemicalBook CAS DataBase List 2H-PYRAZOLE-3-CARBALDEHYDE
3920-50-1

2H-PYRAZOLE-3-CARBALDEHYDE synthesis

1synthesis methods
3-(DIMETHOXYMETHYL)-1H-PYRAZOLE

111573-59-2

2H-PYRAZOLE-3-CARBALDEHYDE

3920-50-1

The general procedure for the synthesis of 3-pyrazolecarboxaldehyde from 3-dimethoxymethyl-1H-pyrazole: 2.3 kg of formic acid was added slowly and dropwise to 15.5 kg of an aqueous solution containing 13.8 kg of 3-dimethoxymethyl-1H-pyrazole at 0-15 °C. Subsequently, the reaction mixture was magnetically stirred at 25 °C for 12 h. A light yellow solid was obtained upon completion of the reaction. The precipitate was separated by filtration and the filter cake was washed with 10 L of water to give 643 g of the final yellow solid product 3-pyrazolecarboxaldehyde.

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Yield:-

Reaction Conditions:

with manganese(IV) oxide in N,N-dimethyl-formamide at 70;

References:

Lee, Eun;An, Ying;Kwon, Junhee;Kim, Keun Il;Jeon, Raok [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 14,p. 3614 - 3622]

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