(2R,3S)-3-methylpyrrolidine-2-carboxylic acid synthesis

1synthesis methods

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.) LDA; 2.) zinc bromide; 3.) H₃O⁽¹⁺⁾ / 1.) Et₂O; 2.) Et₂O, -40 deg C to r.t.
2: hydrogen
3: OH^(1-)

References:

Lorthiois, Edwige;Marek, Ilane;Normant Jean-F., J.-F. [Tetrahedron Letters,1997,vol. 38,# 1,p. 89 - 92]

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