(2S)-2-(methylamino)propanamide synthesis
- Product Name:(2S)-2-(methylamino)propanamide
- CAS Number:55988-12-0
- Molecular formula:C4H10N2O
- Molecular Weight:102.14
![Propanamide, 2-[[(4-methylphenyl)sulfonyl]oxy]-, (2R)-](/CAS/20210305/GIF/118119-58-7.gif)
Yield:55988-12-0 22%
Reaction Conditions:
with potassium carbonate in tetrahydrofuran;acetonitrile at 20; for 72 h;
Steps:
49; 75.ii (2S)-2-(methylamino)propanamide
Mix methviamine (2 M inTHF, 1.0 mL), [(iR>-2-amino-imethvi-2-oxoethy1] 4-methylbenzenesulfonate (243 ing) and K2C03 (419 ing) in acetonitrile (1 mL) and stir atr.t, for 3 days. Filter through Ceiite and wash with acetonitrile. Concentrate the filtrateunder reduced pressure to provide (2S)-2-(methyiamino)propanamide (50%w, 46 mg,22%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.09(3 H, d, J6.94 Hz), 1.84(1 H, hr s),2.19 (3 H, s), 2.86 (1 H, q, J6.81 Hz), 6.94 (1 H, br s), 7.25 (1 H, hr s).
References:
WO2017/192385,2017,A1 Location in patent:Page/Page column 50; 66
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