(2S)-4,4-diMethyl-2-PyrrolidineMethanol synthesis
- Product Name:(2S)-4,4-diMethyl-2-PyrrolidineMethanol
- CAS Number:212890-85-2
- Molecular formula:C7H15NO
- Molecular Weight:129.2
221637-35-0
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212890-85-2
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$310.00/100mg
Yield:212890-85-2 94%
Reaction Conditions:
Stage #1: (S)-ethyl 4,4-dimethyl-5-oxopyrrolidine-2-carboxylatewith lithium aluminium tetrahydride in tetrahydrofuran; for 8 h;Reflux;
Stage #2: with water;sodium hydroxide
Steps:
12.C
- Preparation of Compound Int-12d lnt-12c lnt-12dA suspension of LiAIH4 (16.2 g, 0.44 mol) and compound Int-12c (11.2 g, 54.8 mmol) in THF (200 mL) was allowed to stir under reflux for 8 hours. After successive addition of 17 mL of water, 17 mL of 10% aq NaOH, and 51 mL of water, and filtration, the filtrate was concentrated in vacuo to provide compound Int-12d (6.7 g, 94% yield).
References:
WO2012/41227,2012,A1 Location in patent:Page/Page column 86
156088-46-9
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212890-85-2
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$310.00/100mg
![(S)-3,3,6,6-TETRAMETHYLTETRAHYDROPYRROLO[1,2-C]OXAZOL-5(3H)-ONE](/CAS/20150408/GIF/CB92729393.gif)
156088-45-8
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212890-85-2
16 suppliers
$310.00/100mg
158392-80-4
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$339.63/1g
212890-85-2
16 suppliers
$310.00/100mg