3-(1-cyanoethyl)benzoyl chloride synthesis

Yield:42872-29-7 100%

Reaction Conditions:

with thionyl chloride for 3 h;Heating / reflux;

Steps:

A

Commercial 2-[(3-carboxy)phenyl]propionitrile (1.0 g, 5.70 mmol) was dissolved in SOCl₂ (5 mL) and the resulting solution was left stirring at reflux 3h. After cooling at room temperature, the mixture was evaporated under reduced pressure to obtain 2- [(3-chlorocarbonyl)phenyl]propionitrile as yellow oil in nearly quantitative yield.

References:

WO2006/63999,2006,A1 Location in patent:Page/Page column 14-15