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ChemicalBook CAS DataBase List 3-(1H-BENZOIMIDAZOL-2-YL)-4-CHLORO-PHENYLAMINE
313402-16-3

3-(1H-BENZOIMIDAZOL-2-YL)-4-CHLORO-PHENYLAMINE synthesis

7synthesis methods
-

Yield:313402-16-3 89.9%

Reaction Conditions:

with hydrogenchloride;zinc in ethanol;water; for 12 h;Reflux;

Steps:

6 2-(2-chloro-5-aminophenyl)-1H-benzimidazole

Dissolve 2-(2-chloro-5-nitrophenyl)-1H-benzimidazole (3.005g, 10.98mmol) in 40ml of ethanol, add zinc powder (3.57g, 55mmol) and 5ml of concentrated hydrochloric acid, stir and reflux for 10h . Cooled to room temperature, filtered through diatomaceous earth, the filtrate was dried and concentrated and column chromatography to obtain the target compound, yellow powder 2.405g, yield 89.9%.

References:

CN111039983,2020,A Location in patent:Paragraph 0045-0048