3-(1H-BENZOIMIDAZOL-2-YL)-4-CHLORO-PHENYLAMINE synthesis
- Product Name:3-(1H-BENZOIMIDAZOL-2-YL)-4-CHLORO-PHENYLAMINE
- CAS Number:313402-16-3
- Molecular formula:C13H10ClN3
- Molecular Weight:243.69
54255-79-7
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313402-16-3
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Yield:313402-16-3 89.9%
Reaction Conditions:
with hydrogenchloride;zinc in ethanol;water; for 12 h;Reflux;
Steps:
6 2-(2-chloro-5-aminophenyl)-1H-benzimidazole
Dissolve 2-(2-chloro-5-nitrophenyl)-1H-benzimidazole (3.005g, 10.98mmol) in 40ml of ethanol, add zinc powder (3.57g, 55mmol) and 5ml of concentrated hydrochloric acid, stir and reflux for 10h . Cooled to room temperature, filtered through diatomaceous earth, the filtrate was dried and concentrated and column chromatography to obtain the target compound, yellow powder 2.405g, yield 89.9%.
References:
CN111039983,2020,A Location in patent:Paragraph 0045-0048
349406-06-0
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313402-16-3
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25784-91-2
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313402-16-3
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313402-16-3
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54255-74-2
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313402-16-3
39 suppliers
$185.00/500mg