3-[2-(4-CHLORO-PHENYLAMINO)-ETHYL]-PHENOL synthesis

Yield:295319-83-4 83%

Steps:

37.A A.

A. 3-{2-[(4-Chlorophenyl)amino]ethyl}phenol The title compound was prepared as described in Example 34.D, using N-(4-chlorophenyl)-2-(3-hydroxyphenyl)acetamide (2.0 g, 7.64 mmol) to provide the title compound (1.569 g, 83% yield):¹H NMR (CDCl₃) 7.19 (dd, 1H), 7.10-7.14 (m, 2H), 6.78 (m, 1H), 6.69-6.73 (m, 2H), 6.50-6.55 (m, 2H), 3.66 (br, 1H), 3.36 (t, 2H), 2.86 (t, 2H), 2.05 (s, 1H); ES-MS (m/z) 248 [M+H]⁺.

References:

US6436923,2002,B1