3-(2,5-dihydro-1H-pyrrol-1-yl)propan-1-amine synthesis

Yield:37632-58-9 97%

Reaction Conditions:

with diisobutylaluminium hydride in dichloromethane;toluene at 20;

Steps:

8.2 8.2-1-(3-Aminopropyl)pyrroline

8.2-1-(3-Aminopropyl)pyrroline 0.024 g of 1M diisobutylaluminum hydride in toluene is added to a solution of 1.00 g (0.0089 mol) of 1-(2-cyanoethyl)pyrroline in 20 ml of dichloromethane. The mixture is stirred overnight at ambient temperature. The solution is treated with sodium sulfate decahydrate. The mixture is stirred for half an hour. The inorganic phases are filtered and the filtrate is concentrated to dryness, so as to obtain 1.00 g of a colorless oil. Yield: 97% Mp=Oil ¹H-NMR (CD₃Cl)δ(ppm): 5.75 (2H, s), 3.47 (4H, s), 2.75 (2H, t), 2.56 (2H, t), 1.69 (2H, q).

References:

US2007/105834,2007,A1 Location in patent:Page/Page column 8